Yeah it is a bit awkward I have to admit, but it's a fun game so far. I have been a bit addicted to other games since I got it so I haven't played it as much as I'd like to have, but there's still time

I rest the DS on the edge of a table to play so you can use the stylus easily with the right hand but fire with the left. Apparently, though, the right shoulder button has some kind of alternative function though, which I'll never get to use because it's not physically possible unless you are a hand contortionist.
A friend of mine uses the thumb strap thing to play but I hate repositioning my thumb - it feels weird and you get cramps, like when playing Mario 64. Also when you want to press a button on the touch screen it's a bit tricky to see where you're pressing due to a large thumb being in the way. Still at least you can hold the DS with both hands...!